Journal: BMC Cancer

Article Title: Neovascularization of hepatocellular carcinoma in a nude mouse orthotopic liver cancer model: a morphological study using X-ray in-line phase-contrast imaging

doi: 10.1186/s12885-017-3073-3

Figure Lengend Snippet: 3D reconstruction of contrast CT images for HCC neovascularization at weeks 1 to 4 ( a to d , respectively). The selected areas with red dot lines show the tumor regions, ( e to f ) enlarged image of the rectangle region of d, which clearly shows the disorganized distribution and morphology of tumor neovascularization. A large number of avascular regions were observed in the tumors at weeks 3 and 4 ( c , d ), as well as irregular vessel shape with dendritic-like branching ( e ), individual vascular curvature abnormalities ( f ), blood vessel network cluster structure ( g ), a large number of tiny and curved vessels derived from a few thick vessels ( h , red arrows ), and compressed tumor edge or peripheral vasculature ( c , d )

Article Snippet: Three-dimensional reconstruction was obtained using the VG Studio Max 3D reconstruction software (version 2.1, Volume Graphics GmbH, Germany).

Techniques: Derivative Assay